AUTHOR=McBride Amanda , Houtmann Sarah , Wilde Lindsay , Vigil Carlos , Eischen Christine M. , Kasner Margaret , Palmisiano Neil TITLE=The Role of Inhibition of Apoptosis in Acute Leukemias and Myelodysplastic Syndrome JOURNAL=Frontiers in Oncology VOLUME=9 YEAR=2019 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2019.00192 DOI=10.3389/fonc.2019.00192 ISSN=2234-943X ABSTRACT=

Avoidance of apoptosis is a key mechanism that malignancies, including acute leukemias and MDS, utilize in order to proliferate and resist chemotherapy. Recently, venetoclax, an inhibitor of the anti-apoptotic protein BCL-2, has been approved for the treatment of upfront AML in an unfit, elderly population. This paper reviews the pre-clinical and clinical data for apoptosis inhibitors currently in development for the treatment of AML, ALL, and MDS.