AUTHOR=Liu Shaochuan , Qin Tingting , Jia Yanan , Li Kai 

TITLE=PD-L1 Expression Is Associated With VEGFA and LADC Patients' Survival

JOURNAL=Frontiers in Oncology

VOLUME=9

YEAR=2019

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2019.00189

DOI=10.3389/fonc.2019.00189

ISSN=2234-943X

ABSTRACT=<p><bold>Objectives:</bold> To elucidate the relationship between VEGFA and PD-L1 expression in lung adenocarcinoma (LADC).</p><p><bold>Methods:</bold> PD-L1 and VEGFA expression were determined by immunohistochemistry with H-score on formalin-fixed paraffin-embedded resected LADC specimens of 129 cases.</p><p><bold>Results:</bold> High PD-L1 expression in 53 (41.1%) patients, high VEGFA expression in 65 (50.4%), and co-expression in 18 (14.0%) were observed. Inverse correlation between expression of PD-L1 and VEGFA was found (<italic>P</italic> = 0.002, <italic>r</italic> = −0.274). VEGFA and PD-L1 expression were not significantly associated with the clinicopathological features. High PD-L1 expression was significantly association with all patients' poor progression-free survival and overall survival in a univariate analysis, but there was no significantly association with high VEGFA expression and prognosis. Co-expression of PD-L1 and VEGFA exhibited a worst overall survival compared to negative groups (<italic>P</italic> = 0.005).</p><p><bold>Conclusions:</bold> These findings indicate that high PD-L1 expression could impact both poor overall survival and progression-free survival in patients with resected LADC. Co-expression of PD-L1 and VEGFA may be considered as an important prognostic factor for patients with resected lung adenocarcinoma.</p>