AUTHOR=Zhou Quan , Zhang Fan , He Ze , Zuo Man-Zhen 

TITLE=E2F2/5/8 Serve as Potential Prognostic Biomarkers and Targets for Human Ovarian Cancer

JOURNAL=Frontiers in Oncology

VOLUME=9

YEAR=2019

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2019.00161

DOI=10.3389/fonc.2019.00161

ISSN=2234-943X

ABSTRACT=<p><italic>E2Fs</italic> are a family of pivotal transcription factors. Accumulative evidence indicates that aberrant expression or activation of <italic>E2Fs</italic> is a common phenomenon in malignances, and significant associations have been noted between <italic>E2Fs</italic> and tumorigenesis or progression in a wide range of cancers. However, the expression patterns and exact roles of each <italic>E2F</italic> contributing to tumorigenesis and progression of ovarian cancer (OC) have not yet been elucidated. In this study, we investigated the distinct expression and prognostic value of E2Fs in patients with OC by analyzing a series of databases, including ONCOMINE, GEPIA, cBioPortal, Metascape, and Kaplan–Meier plotter. The mRNA expression levels of <italic>E2F1/3/5/8</italic> were found to be significantly upregulated in patients with OC and were obviously associated with tumor stage for OC. Aberrant expression of <italic>E2F2/5/7/8</italic> was found to be associated with the clinical outcomes of patients with OC. These results suggest that <italic>E2F2/5/8</italic> might serve as potential prognostic biomarkers and targets for OC. However, future studies are required to validate our findings and promote the clinical utility of <italic>E2Fs</italic> in OC.</p>