AUTHOR=Njoroge Rose N. , Vatapalli Rajita J. , Abdulkadir Sarki A. TITLE=Organoids Increase the Predictive Value of in vitro Cancer Chemoprevention Studies for in vivo Outcome JOURNAL=Frontiers in Oncology VOLUME=9 YEAR=2019 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2019.00077 DOI=10.3389/fonc.2019.00077 ISSN=2234-943X ABSTRACT=
Epidemiological and preclinical data suggest that antioxidants are protective against prostate cancer whose pathogenesis has been linked to oxidative stress. However, the selenium and vitamin E Cancer Prevention Trial (SELECT), found no efficacy for selenium in reducing prostate cancer incidence while vitamin E was associated with an increased risk of the disease. These results have called in to question the models used in preclinical chemoprevention efficacy studies and their ability to predict