AUTHOR=Lin Aifen , Zhang Xia , Zhang Rui- Li , He Xiao-Fang , Zhang Jian-Gang , Yan Wei-Hua 

TITLE=Prognostic and Risk Stratification Value of Lesion MACC1 Expression in Colorectal Cancer Patients

JOURNAL=Frontiers in Oncology

VOLUME=9

YEAR=2019

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2019.00028

DOI=10.3389/fonc.2019.00028

ISSN=2234-943X

ABSTRACT=<p>The up-regulated metastasis-associated in colon cancer 1 (MACC1) expression and its clinical significance has been explored in a varity of malignancies. In this study, lesion MACC1 expression in 503 CRC patients (<italic>N</italic><sub>colon</sub> = 332, <italic>N</italic><sub>rectal</sub> = 171) were analyzed with immunohistochemistry, and its correlation with clinical parameters, patient survival, and its impact on prognostic stratification were evaluated. Data revealed the survival of patient with MACC1<sub>high</sub> is markedly worse than that of MACC1<sub>low</sub> (mean overall survival: 80.1 vs. 90.4 months; <italic>p</italic> = 0.001) and is an independent prognostic predictor (hazard ratio = 1.533; <italic>p</italic> = 0.005). More importantly, for the first time, we demonstrated that MACC1 status exhibited a significantly prognostic power for stratified clinical parameters such as patient age and gender, particular TNM status, and distinct AJCC disease stage. In summary, our findings indicated that MACC1 is a valuable prognostic and risk stratification biomarker for colorectal cancer patients.</p>