AUTHOR=Yu Wenxi , Tang Lina , Lin Feng , Yao Yang , Shen Zan TITLE=DGKZ Acts as a Potential Oncogene in Osteosarcoma Proliferation Through Its Possible Interaction With ERK1/2 and MYC Pathway JOURNAL=Frontiers in Oncology VOLUME=8 YEAR=2019 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2018.00655 DOI=10.3389/fonc.2018.00655 ISSN=2234-943X ABSTRACT=
Osteosarcoma (OS) is one of the most common primary bone tumors in children and young adults. The majority of osteosarcoma patients have limited alternative therapeutic options and metastatic patients generally have a poor prognosis. Thus, it is important to explore novel effective therapeutic targets in the treatment of osteosarcoma. Diacylglycerol kinase zeta (DGKZ) is a recently identified gene potentially associated with certain human carcinogenesis. However, the role of DGKZ in proliferation of osteosarcoma is still unclear. In this study, DGKZ's expression was firstly investigated in OS tumor samples and correlated with poor outcome in OS patients. Silence of DGKZ by shRNA hampered osteosarcoma cell growth and promoted cell apoptosis