AUTHOR=Eliassen Eva , Lum Emily , Pritchett Joshua , Ongradi Joseph , Krueger Gerhard , Crawford John R. , Phan Tuan L. , Ablashi Dharam , Hudnall Stanley David TITLE=Human Herpesvirus 6 and Malignancy: A Review JOURNAL=Frontiers in Oncology VOLUME=8 YEAR=2018 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2018.00512 DOI=10.3389/fonc.2018.00512 ISSN=2234-943X ABSTRACT=
In order to determine the role of human herpesvirus 6 (HHV-6) in human disease, several confounding factors, including methods of detection, types of controls, and the ubiquitous nature of the virus, must be considered. This is particularly problematic in the case of cancer, in which rates of detection vary greatly among studies. To determine what part, if any, HHV-6 plays in oncogenesis, a review of the literature was performed. There is evidence that HHV-6 is present in certain types of cancer; however, detection of the virus within tumor cells is insufficient for assigning a direct role of HHV-6 in tumorigenesis. Findings supportive of a causal role for a virus in cancer include presence of the virus in a large proportion of cases, presence of the virus in most tumor cells, and virus-induced