AUTHOR=Wang Yu-Fan , Li Bo-Wen , Sun Shuai , Li Xiang , Su Wen , Wang Zhi-Hong , Wang Feng , Zhang Wei , Yang Hong-Yu 

TITLE=Circular RNA Expression in Oral Squamous Cell Carcinoma

JOURNAL=Frontiers in Oncology

VOLUME=8

YEAR=2018

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2018.00398

DOI=10.3389/fonc.2018.00398

ISSN=2234-943X

ABSTRACT=<p>Circular RNA (circRNA) is a type of non-coding RNA molecule that affects the cellular regulatory network by sequestering microRNA (miRNA) like a sponge. This study was performed to identify differentially-expressed circRNA in oral squamous cell carcinomas (OSCCs). By high-throughput sequencing, microarray circRNA expression profiles were acquired from patients with OSCCs (<italic>n</italic> = 8) and controls (<italic>n</italic> = 8), which totaled 1921 existing circRNA molecules and 10021 novel circRNA molecules. Most of the circular RNA is from exons and distributed in the No. 1 and 2 chromosomes. Eight up-regulated and down-regulated circRNA molecules were identified as differentially-expressed in OSCCs. Among this, the expression of circ_000334, circ_006740, and circ_006371 are significantly down-regulated in 42 pairs of samples, which means that these circRNA molecules might be implicated in oncogenesis and development of OSCCs.</p>