AUTHOR=Cannino Giuseppe , Ciscato Francesco , Masgras Ionica , Sánchez-Martín Carlos , Rasola Andrea 

TITLE=Metabolic Plasticity of Tumor Cell Mitochondria

JOURNAL=Frontiers in Oncology

VOLUME=8

YEAR=2018

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2018.00333

DOI=10.3389/fonc.2018.00333

ISSN=2234-943X

ABSTRACT=<p>Mitochondria are dynamic organelles that exchange a multiplicity of signals with other cell compartments, in order to finely adjust key biological routines to the fluctuating metabolic needs of the cell. During neoplastic transformation, cells must provide an adequate supply of the anabolic building blocks required to meet a relentless proliferation pressure. This can occur in conditions of inconstant blood perfusion leading to variations in oxygen and nutrient levels. Mitochondria afford the bioenergetic plasticity that allows tumor cells to adapt and thrive in this ever changing and often unfavorable environment. Here we analyse how mitochondria orchestrate the profound metabolic rewiring required for neoplastic growth.</p>