AUTHOR=Sun Yadong , Duan Fujiao , Liu Weigang , Peng Zhen , Dai Liping , Feng Yajing , Yang Zhenxing , Shang Jia , Wang Kaijuan 

TITLE=Comprehensive Assessment of the Relationship Between MicroRNA-124 and the Prognostic Significance of Cancer

JOURNAL=Frontiers in Oncology

VOLUME=8

YEAR=2018

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2018.00252

DOI=10.3389/fonc.2018.00252

ISSN=2234-943X

ABSTRACT=<sec id="ST1"><title>Background</title><p>Numerous studies have demonstrated the presence of microRNA-124 abnormalities involving gene expression, methylation, and single nucleotide polymorphism (SNP) in multiple and diverse cancers, but the prognostic value of these abnormalities in cancer remains inconclusive.</p></sec><sec id="ST2"><title>Objective</title><p>The aim of this study is to determine the prognostic value of miR-124 in cancer.</p></sec><sec id="ST3"><title>Methods</title><p>We scrutinized the electronic databases and estimate the association between miR-124 expression, methylation and single nucleotide polymorphisms (SNPs), and prognosis in cancers. The pooled hazard ratios with 95% confidence intervals (CIs) for overall survival (OS), and disease-free survival/recurrence-free survival (RFS)/progression-free survival (PFS) were calculated to estimate the effects of miR-124 expression, methylation, and SNPs on cancer prognosis. The Quality in Prognosis Studies and Newcastle-Ottawa Scale were utilized to assess the quality of included studies.</p></sec><sec id="ST4"><title>Results</title><p>A total of 20 studies involving 3,574 participants were analyzed in evidence synthesis. Our findings showed that the low expression of miR-124 was significantly associated with poor OS (HR = 2.37, 95% CI: 1.91–2.94, <italic>P</italic> = 0.00; HR = 3.10, 95% CI: 2.04–4.70, <italic>P</italic> = 0.00) and PFS/RFS (HR = 2.21, 95% CI: 1.50–3.26, <italic>P</italic> = 0.00; HR = 2.12, 95% CI: 1.20–3.74, <italic>P</italic> = 0.00). The hyper-methylation of miR-124 was associated with poor OS (HR = 2.09, 95% CI: 1.48–2.95, <italic>P</italic> = 0.00) and PFS (HR = 3.70, 95% CI: 1.72–7.97, <italic>P</italic> = 0.00) (Table <xref ref-type="table" rid="T3">3</xref>). The patients carrying with Allele C of miR-124 rs5315649 had a worse OS (HR = 1.50, 95% CI: 1.09–2.07, <italic>P</italic> = 0.00) and PFS (HR = 1.67, 95% CI: 1.20–2.33, <italic>P</italic> = 0.00) than the carriers with Allele G.</p></sec><sec id="ST5"><title>Conclusion</title><p>The low expression and hyper-methylation of miR-124 was strongly associated with poor prognosis, and genetic variations of miR-124 rs531564 affected prognosis in cancer patients.</p></sec>