AUTHOR=Yasmin-Karim Sayeda , Moreau Michele , Mueller Romy , Sinha Neeharika , Dabney Raymond , Herman Allen , Ngwa Wilfred 

TITLE=Enhancing the Therapeutic Efficacy of Cancer Treatment With Cannabinoids

JOURNAL=Frontiers in Oncology

VOLUME=8

YEAR=2018

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2018.00114

DOI=10.3389/fonc.2018.00114

ISSN=2234-943X

ABSTRACT=<p>Over the years, many <italic>in vitro</italic> and <italic>in vivo</italic> studies have shown the antineoplastic effects of cannabinoids (CBDs), with reports advocating for investigations of combination therapy approaches that could better leverage these effects in clinical translation. This study explores the potential of combination approaches employing CBDs with radiotherapy (RT) or smart biomaterials toward enhancing therapeutic efficacy during treatment of pancreatic and lung cancers. In <italic>in vitro</italic> studies, clonogenic assay results showed greater effective tumor cell killing, when combining CBDs and RT. Meanwhile, <italic>in vivo</italic> study results revealed major increase in survival when employing smart biomaterials for sustained delivery of CBDs to tumor cells. The significance of these findings, considerations for further research, and viable roadmap to clinical translation are discussed.</p>