AUTHOR=Porcari Andreia M. , Negrão Fernanda , Tripodi Guilherme Lucas , Pitta Denise Rocha , Campos Elisabete Aparecida , Montis Douglas Munhoz , Martins Aline M. A. , Eberlin Marcos N. , Derchain Sophie F. M. TITLE=Molecular Signatures of High-Grade Cervical Lesions JOURNAL=Frontiers in Oncology VOLUME=8 YEAR=2018 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2018.00099 DOI=10.3389/fonc.2018.00099 ISSN=2234-943X ABSTRACT=
Cervical cancer is the fourth most common neoplasia in women and the infection with human papilloma virus (HPV) is its necessary cause. Screening methods, currently based on cytology and HPV DNA tests, display low specificity/sensitivity, reducing the efficacy of cervical cancer screening programs. Herein, molecular signatures of cervical cytologic specimens revealed by liquid chromatography-mass spectrometry (LC-MS), were tested in their ability to provide a metabolomic screening for cervical cancer. These molecules were tested whether they could clinically differentiate insignificant HPV infections from precancerous lesions. For that, high-grade squamous intraepithelial lesions (HSIL)-related metabolites were compared to those of no cervical lesions in women with and without HPV infection. Samples were collected from women diagnosed with normal cervix (