AUTHOR=Sylman Joanna L. , Mitrugno Annachiara , Atallah Michelle , Tormoen Garth W. , Shatzel Joseph J. , Tassi Yunga Samuel , Wagner Todd H. , Leppert John T. , Mallick Parag , McCarty Owen J. T. 

TITLE=The Predictive Value of Inflammation-Related Peripheral Blood Measurements in Cancer Staging and Prognosis

JOURNAL=Frontiers in Oncology

VOLUME=8

YEAR=2018

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2018.00078

DOI=10.3389/fonc.2018.00078

ISSN=2234-943X

ABSTRACT=<p>In this review, we discuss the interaction between cancer and markers of inflammation (such as levels of inflammatory cells and proteins) in the circulation, and the potential benefits of routinely monitoring these markers in peripheral blood measurement assays. Next, we discuss the prognostic value and limitations of using inflammatory markers such as neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios and C-reactive protein measurements. Furthermore, the review discusses the benefits of combining multiple types of measurements and longitudinal tracking to improve staging and prognosis prediction of patients with cancer, and the ability of novel <italic>in silico</italic> frameworks to leverage this high-dimensional data.</p>