AUTHOR=Kenny Timothy C. , Manfredi Giovanni , Germain Doris 

TITLE=The Mitochondrial Unfolded Protein Response as a Non-Oncogene Addiction to Support Adaptation to Stress during Transformation in Cancer and Beyond

JOURNAL=Frontiers in Oncology

VOLUME=7

YEAR=2017

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2017.00159

DOI=10.3389/fonc.2017.00159

ISSN=2234-943X

ABSTRACT=<p>Upon accumulation of misfolded proteins in the mitochondria, the mitochondrial unfolded protein response (UPR<sup>mt</sup>) is activated. This review focuses on the role of this response in cancer. We discuss evidence that during transformation, the UPR<sup>mt</sup> may play an essential role in the maintenance of the integrity of the mitochondria in the face of increased oxidative stress. However, the role of the UPR<sup>mt</sup> in other diseases is also emerging and is therefore also briefly discussed.</p>