AUTHOR=Lewis Philip , Erren Thomas C. TITLE=Perinatal Light Imprinting of Circadian Clocks and Systems (PLICCS): The PLICCS and Cancer Hypothesis JOURNAL=Frontiers in Oncology VOLUME=7 YEAR=2017 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2017.00044 DOI=10.3389/fonc.2017.00044 ISSN=2234-943X ABSTRACT=
Circadian disruption is associated with sleep, mood, and metabolic disorders, and—according to the International Agency for Research on Cancer—even with cancer. Mechanistically, the source of disease may be circadian system instability which likely arises during development. In animal experiments, both low perinatal light:dark ratios and chronic perinatal photoperiod phase shifting yield enduring, detrimental effects on neuroendocrine physiology