AUTHOR=Hasan Shaakir , Ricco Anthony , Jenkins Kaylette , Lanciano Rachelle , Hanlon Alexandra , Lamond John , Yang Jun , Feng Jing , Good Michael , Noumoff Joel , Brady Luther 

TITLE=Survival and Control Prognosticators of Recurrent Gynecological Malignancies of the Pelvis and Para-aortic Region Treated with Stereotactic Body Radiation Therapy

JOURNAL=Frontiers in Oncology

VOLUME=6

YEAR=2016

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2016.00249

DOI=10.3389/fonc.2016.00249

ISSN=2234-943X

ABSTRACT=<sec id="ST1"><title>Purpose</title><p>To define prognostic factors associated with improved survival and local control (LC) for gynecologic cancer recurrences limited to the pelvis and para-aortic (PA) region using stereotactic body radiation therapy (SBRT).</p></sec><sec id="ST2"><title>Methods</title><p>Between 2/2008 and 7/2014, 30 women (35 targets) with pelvic or PA recurrence of endometrioid (<italic>n</italic> = 12), cervical (<italic>n</italic> = 11), ovarian (<italic>n</italic> = 3), uterine-serous (<italic>n</italic> = 2), or carcinosarcoma (<italic>n</italic> = 2) cancer were treated with SBRT. Eleven recurrences were located in the central pelvis, 11 along the pelvic sidewall (PSW), and 13 in the PA region.</p></sec><sec id="ST3"><title>Results</title><p>Five-year survival for all patients was 42% with a median survival of 43.4 months. Multivariate analysis revealed better performance status (PS), and smaller clinical tumor volume was significant for improved survival (<italic>p</italic> &lt; 0.05).</p></sec><sec id="ST4"><title>Conclusion</title><p>SBRT is a local therapy for recurrent gynecological malignancies in the pelvis and PA region with curative potential. SBRT is especially effective for LC when targeting PSW or PA recurrence and for patients with a cervical/endometrioid uterine primary. Survival is improved for patients with better PS and smaller recurrence volume prior to SBRT.</p></sec>