AUTHOR=Pakkiriswami Shanmugasundaram , Couto Africa , Nagarajan Usha , Georgiou Marios 

TITLE=Glycosylated Notch and Cancer

JOURNAL=Frontiers in Oncology

VOLUME=6

YEAR=2016

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2016.00037

DOI=10.3389/fonc.2016.00037

ISSN=2234-943X

ABSTRACT=<p>Glycosylation is one of the key components influencing several signaling pathways implicated in cell survival and growth. The Notch signaling pathway plays a pivotal role in numerous cell fate specifications during metazoan development. Both Notch and its ligands are repeatedly glycosylated by the addition of sugar moieties, such as O-fucose, O-glucose, or O-xylose, to bring about structural and functional changes. Disruption to glycosylation processes of Notch proteins result in developmental disorders and disease, including cancer. This review summarizes the importance and recent updates on the role of glycosylated Notch proteins in tumorigenesis and tumor metastasis.</p>