AUTHOR=van der Kemp Wybe J. M. , Stehouwer Bertine L. , Runge Jurgen H. , Wijnen Jannie P. , Nederveen Aart J. , Luijten Peter R. , Klomp Dennis W. J.
TITLE=Glycerophosphocholine and Glycerophosphoethanolamine Are Not the Main Sources of the In Vivo31P MRS Phosphodiester Signals from Healthy Fibroglandular Breast Tissue at 7 T
JOURNAL=Frontiers in Oncology
VOLUME=6
YEAR=2016
URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2016.00029
DOI=10.3389/fonc.2016.00029
ISSN=2234-943X
ABSTRACT=PurposeThe identification of the phosphodiester (PDE) 31P MR signals in the healthy human breast at ultra-high field.
MethodsIn vivo31P MRS measurements at 7 T of the PDE signals in the breast were performed investigating the chemical shifts, the transverse- and the longitudinal relaxation times. Chemical shifts and transverse relaxation times were compared with non-ambiguous PDE signals from the liver.
ResultsThe chemical shifts of the PDE signals are shifted −0.5 ppm with respect to glycerophosphocholine (GPC) and glycerophosphoethanolamine (GPE), and the transverse and longitudinal relaxation times for these signals are a factor 3 to 4 shorter than expected for aqueous GPC and GPE.
ConclusionThe available experimental evidence suggests that GPC and GPE are not the main source of the PDE signals measured in fibroglandular breast tissue at 7 T. These signals may predominantly originate from mobile phospholipids.