AUTHOR=Geier Brian , Kurmashev Dias , Kurmasheva Raushan T. , Houghton Peter J. TITLE=Preclinical Childhood Sarcoma Models: Drug Efficacy Biomarker Identification and Validation JOURNAL=Frontiers in Oncology VOLUME=5 YEAR=2015 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2015.00193 DOI=10.3389/fonc.2015.00193 ISSN=2234-943X ABSTRACT=

Over the past 35 years, cure rates for pediatric cancers have increased dramatically. However, it is clear that further dose intensification using cytotoxic agents or radiation therapy is not possible without enhancing morbidity and long-term effects. Consequently, novel, less genotoxic, agents are being sought to complement existing treatments. Here, we discuss preclinical human tumor xenograft models of pediatric cancers that may be used practically to identify novel agents for soft tissue and bone sarcomas, and “omics” approaches to identifying biomarkers that may identify sensitive and resistant tumors to these agents.