AUTHOR=Vetro Calogero , Romano Alessandra , Ancora Flavia , Coppolino Francesco , Brundo Maria V. , Raccuia Salvatore A. , Puglisi Fabrizio , Tibullo Daniele , La Cava Piera , Giallongo Cesarina , Parrinello Nunziatina L. 

TITLE=Clinical Impact of the Immunome in Lymphoid Malignancies: The Role of Myeloid-Derived Suppressor Cells

JOURNAL=Frontiers in Oncology

VOLUME=5

YEAR=2015

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2015.00104

DOI=10.3389/fonc.2015.00104

ISSN=2234-943X

ABSTRACT=<p>The better definition of the mutual sustainment between neoplastic cells and immune system has been translated from the bench to the bedside acquiring value as prognostic factor. Additionally, it represents a promising tool for improving therapeutic strategies. In this context, myeloid-derived suppressor cells (MDSCs) have gained a central role in tumor developing with consequent therapeutic implications. In this review, we will focus on the biological and clinical impact of the study of MDSCs in the settings of lymphoid malignancies.</p>