AUTHOR=Geltzeiler Mathew , Li Guangheng , Abraham Jinu , Keller Charles TITLE=The Case for Primary Salivary Rhabdomyosarcoma JOURNAL=Frontiers in Oncology VOLUME=5 YEAR=2015 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2015.00074 DOI=10.3389/fonc.2015.00074 ISSN=2234-943X ABSTRACT=
Rhabdomyosarcomas of the parotid and submandibular glands have the histological appearance of a skeletal muscle tumor yet can be found in tissue with no striated muscular elements. We examine the potential cell-of-origin for rhabdomyosarcoma and whether salivary tumors represent primary malignancy or metastasis. We have previously established genetically engineered mouse models of rhabdomyosarcoma. In these mice, rhabdomyosarcoma is only induced when a