AUTHOR=Callahan Margaret K. , Postow Michael A. , Wolchok Jedd D. TITLE=CTLA-4 and PD-1 Pathway Blockade: Combinations in the Clinic JOURNAL=Frontiers in Oncology VOLUME=4 YEAR=2015 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2014.00385 DOI=10.3389/fonc.2014.00385 ISSN=2234-943X ABSTRACT=

Checkpoint blocking antibodies targeting regulatory molecules on T cells such as CTLA-4 and PD-1 have reinvigorated the field of cancer immunotherapy. These agents have demonstrated clinical activity across a variety of tumor types. Now that safety and clinical activity has been demonstrated in the monotherapy setting, the field is moving in the direction of testing novel combinations.