AUTHOR=Huang Jing-Tao , Wang Jin , Srivastava Vibhuti , Sen Subrata , Liu Song-Mei
TITLE=MicroRNA Machinery Genes as Novel Biomarkers for Cancer
JOURNAL=Frontiers in Oncology
VOLUME=4
YEAR=2014
URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2014.00113
DOI=10.3389/fonc.2014.00113
ISSN=2234-943X
ABSTRACT=
MicroRNAs (miRNAs) directly and indirectly affect tumorigenesis. To be able to perform their myriad roles, miRNA machinery genes, such as Drosha, DGCR8, Dicer1, XPO5, TRBP, and AGO2, must generate precise miRNAs. These genes have specific expression patterns, protein-binding partners, and biochemical capabilities in different cancers. Our preliminary analysis of data from The Cancer Genome Atlas consortium on multiple types of cancer revealed significant alterations in these miRNA machinery genes. Here, we review their biological structures and functions with an eye toward understanding how they could serve as cancer biomarkers.