AUTHOR=Jacoby Elad , Chien Christopher D. , Fry Terry J. TITLE=Murine Models of Acute Leukemia: Important Tools in Current Pediatric Leukemia Research JOURNAL=Frontiers in Oncology VOLUME=Volume 4 - 2014 YEAR=2014 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2014.00095 DOI=10.3389/fonc.2014.00095 ISSN=2234-943X ABSTRACT=
Leukemia remains the most common diagnosis in pediatric oncology and, despite dramatic progress in upfront therapy, is also the most common cause of cancer-related death in children. Much of the initial improvement in outcomes for acute lymphoblastic leukemia (ALL) was due to identification of cytotoxic agents that are active against leukemia followed by the recognition that combination of these cytotoxic agents and prolonged therapy are essential for cure. Recent data demonstrating lack of progress in patients for whom standard chemotherapy fails suggests that the ability to improve outcome for these children will not be dramatically impacted through more intensive or newer cytotoxic agents. Thus, much of the recent research focus has been in the area of improving our understanding of the genetics and the biology of leukemia. Although