AUTHOR=Mumenthaler Shannon , D'Antonio Gianluca , Preziosi Luigi , Macklin Paul 

TITLE=The Need for Integrative Computational Oncology: An Illustrated Example through MMP-Mediated Tissue Degradation

JOURNAL=Frontiers in Oncology

VOLUME=Volume 3 - 2013

YEAR=2013

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2013.00194

DOI=10.3389/fonc.2013.00194

ISSN=2234-943X

ABSTRACT=Physical oncology is a growing force in cancer research, and it is enhanced by integrative computational oncology: the fusion of novel experiments with mathematical and computational modeling. Computational models must be assessed with accurate numerical methods on correctly-scaled tissues to avoid numerical artifacts that can cloud analysis. Simulation-driven analyses can only be validated by careful experiments. In this perspectives piece, we evaluate a current, widespread model of matrix metalloproteinase-driven tissue degradation during cancer invasion to illustrate that integrative computational oncology may not realize its fullest potential if either of these critical steps is neglected.