AUTHOR=De Thé Hugues , Ivanschitz Lisa , Le Bras Morgane 

TITLE=PML, SUMOylation, and Senescence

JOURNAL=Frontiers in Oncology

VOLUME=3

YEAR=2013

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2013.00171

DOI=10.3389/fonc.2013.00171

ISSN=2234-943X

ABSTRACT=<p>Since its discovery, 25 years ago, promyelocytic leukemia (PML) has been an enigma. Implicated in the oncogenic PML/RARA fusion, forming elusive intranuclear domains, triggering cell death or senescence, controlled by and perhaps controlling SUMOylation… there are multiple PML-related issues. Here we review the reciprocal interactions between PML, senescence, and SUMOylation, notably in the context of cellular transformation.</p>