AUTHOR=Nisole Sébastien , Maroui Mohamed Ali , Mascle Xavier , Aubry Muriel , Chelbi-Alix Mounira K.

TITLE=Differential Roles of PML Isoforms

JOURNAL=Frontiers in Oncology

VOLUME=3

YEAR=2013

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2013.00125

DOI=10.3389/fonc.2013.00125

ISSN=2234-943X

ABSTRACT=<p>The tumor suppressor promyelocytic leukemia (PML) protein is fused to the retinoic acid receptor alpha in patients suffering from acute promyelocytic leukemia (APL). Treatment of APL patients with arsenic trioxide (As<sub>2</sub>O<sub>3</sub>) reverses the disease phenotype by a process involving the degradation of the fusion protein <italic>via</italic> its PML moiety. Several PML isoforms are generated from a single <italic>PML</italic> gene by alternative splicing. They share the same N-terminal region containing the RBCC/tripartite motif but differ in their C-terminal sequences. Recent studies of all the PML isoforms reveal the specific functions of each. Here, we review the nomenclature and structural organization of the PML isoforms in order to clarify the various designations and classifications found in different databases. The functions of the PML isoforms and their differential roles in antiviral defense also are reviewed. Finally, the key players involved in the degradation of the PML isoforms in response to As<sub>2</sub>O<sub>3</sub> or other inducers are discussed.</p>