AUTHOR=Chen Lindi , Tweddle Deborah A.

TITLE=p53, SKP2, and DKK3 as MYCN Target Genes and Their Potential Therapeutic Significance

JOURNAL=Frontiers in Oncology

VOLUME=2

YEAR=2012

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2012.00173

DOI=10.3389/fonc.2012.00173

ISSN=2234-943X

ABSTRACT=<p>Neuroblastoma is the most common extra-cranial solid tumor of childhood. Despite significant advances, it currently still remains one of the most difficult childhood cancers to cure, with less than 40% of patients with high-risk disease being long-term survivors. <italic>MYCN</italic> is a proto-oncogene implicated to be directly involved in neuroblastoma development. Amplification of <italic>MYCN</italic> is associated with rapid tumor progression and poor prognosis. Novel therapeutic strategies which can improve the survival rates whilst reducing the toxicity in these patients are therefore required. Here we discuss genes regulated by MYCN in neuroblastoma, with particular reference to <italic>p53</italic>, <italic>SKP2</italic>, and <italic>DKK3</italic> and strategies that may be employed to target them.</p>