AUTHOR=Austriaco Nicanor 

TITLE=Endoplasmic reticulum involvement in yeast cell death

JOURNAL=Frontiers in Oncology

VOLUME=2

YEAR=2012

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2012.00087

DOI=10.3389/fonc.2012.00087

ISSN=2234-943X

ABSTRACT=<p>Yeast cells undergo programed cell death (PCD) with characteristic markers associated with apoptosis in mammalian cells including chromatin breakage, nuclear fragmentation, reactive oxygen species generation, and metacaspase activation. Though significant research has focused on mitochondrial involvement in this phenomenon, more recent work with both <italic>Saccharomyces cerevisiae</italic> and <italic>Schizosaccharomyces pombe</italic> has also implicated the endoplasmic reticulum (ER) in yeast PCD. This minireview provides an overview of ER stress-associated cell death (ER-SAD) in yeast. It begins with a description of ER structure and function in yeast before moving to a discussion of ER-SAD in both mammalian and yeast cells. Three examples of yeast cell death associated with the ER will be highlighted here including inositol starvation, lipid toxicity, and the inhibition of <italic>N</italic>-glycosylation. It closes by suggesting ways to further examine the involvement of the ER in yeast cell death.</p>