AUTHOR=Yang Ming , Soga Tomoyoshi , Pollard Patrick J., Adam Julie TITLE=The emerging role of fumarate as an oncometabolite JOURNAL=Frontiers in Oncology VOLUME=2 YEAR=2012 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2012.00085 DOI=10.3389/fonc.2012.00085 ISSN=2234-943X ABSTRACT=
The drive to understand how altered cellular metabolism and cancer are linked has caused a paradigm shift in the focus of cancer research. The discovery of a mutated metabolic enzyme, isocitrate dehydrogenase 1, that leads to accumulation of the oncometabolite 2-hydroxyglutarate, provided significant direct evidence that dysfunctional metabolism plays an important role in oncogenesis. Striking parallels exist with the Krebs cycle enzyme fumarate hydratase (