AUTHOR=Tabbo Fabrizio , Barreca Antonella , Piva Roberto , Inghirami Giorgio , Lymphoma Study Group The European T-Cell 

TITLE=ALK signaling and target therapy in anaplastic large cell lymphoma

JOURNAL=Frontiers in Oncology

VOLUME=Volume 2 - 2012

YEAR=2012

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2012.00041

DOI=10.3389/fonc.2012.00041

ISSN=2234-943X

ABSTRACT=The discovery by Morris SW et al. in 1994 of the genes contributing to the t(2;5)(p23;q35) translocation has put the foundation for a molecular based recognition of Anaplastic Large Cell Lymphoma (ALCL) and pointed out the need for a further stratification of T-cell neoplasia. Likewise the detection of ALK genetic lesions among many human cancers has defined unique subsets of cancer patients, providing new opportunities for innovative therapeutic interventions. The objective of this review is to appraise the molecular mechanisms driving ALK-mediated transformation, and to maintain the neoplastic phenotype. The understanding of these events will allow the design and implementation of novel tailored strategies for a well-defined subset of cancer patients.