AUTHOR=Ostrom Quinn , Chen Yanwen , Devine Karen , Wolinsky Yingli , Davitkov Perica , Robbins Sarah , Cherukuri Rajesh , Patel Ashokkumar , Gupta Rajnish , Cohen Mark , Vengoechea Barrios Jaime , Brewer Cathy , Schilero Cathy , Smolenski Kathy , McGraw Mary , Denk Barbara , Naska Theresa , Laube Frances , Steele Ruth , Greene Dale , Kastl Alison , Bell Susan , Aziz Dina , Chiocca E.A. , McPherson Christopher , Warnick Ronald , Barnett Gene H., Sloan Andrew E., Barnholtz-Sloan Jill S., McCulloh Christopher TITLE=Family History of Cancer in Benign Brain Tumor Subtypes Versus Gliomas JOURNAL=Frontiers in Oncology VOLUME=2 YEAR=2012 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2012.00019 DOI=10.3389/fonc.2012.00019 ISSN=2234-943X ABSTRACT=

Purpose: Family history is associated with gliomas, but this association has not been established for benign brain tumors. Using information from newly diagnosed primary brain tumor patients, we describe patterns of family cancer histories in patients with benign brain tumors and compare those to patients with gliomas. Methods: Newly diagnosed primary brain tumor patients were identified as part of the Ohio Brain Tumor Study. Each patient was asked to participate in a telephone interview about personal medical history, family history of cancer, and other exposures. Information was available from 33 acoustic neuroma (65%), 78 meningioma (65%), 49 pituitary adenoma (73.1%), and 152 glioma patients (58.2%). The association between family history of cancer and each subtype was compared with gliomas using unconditional logistic regression models generating odds ratios (ORs) and 95% confidence intervals. Results: There was no significant difference in family history of cancer between patients with glioma and benign subtypes. Conclusion: The results suggest that benign brain tumor may have an association with family history of cancer. More studies are warranted to disentangle the potential genetic and/or environmental causes for these diseases.