AUTHOR=Chuang Shu-Chun , Agudo Antonio , Ahrens Wolfgang , Anantharaman Devasena , Benhamou Simone , Boccia Stefania , Chen Chu , Conway David , Fabianova Eleonora , Hayes Richard B., Healy Claire , Holcatova Ivana , Kjaerheim Kristina , Lagiou Pagona , Lazarus Philip , Macfarlane Tatiana V., Mahimkar Manoj , Mates Dana , Matsuo Keitaro , Merletti Franco , Metspalu Andres , Morgenstern Hal , Muscat Joshua , Cadoni Gabriella , Olshan Andrew F., Purdue Mark , Ramroth Heribert , Rudnai Péter , Schwartz Stephen M., Simonato Lorenzo , Smith Elaine M., Sturgis Erich M., Szeszenia-Dabrowska Neonila , Talamini Renato , Thomsom Peter , Wei Qingyi , Zaridze David , Zhang Zuo-Feng , Znaor Ariana , Brennan Paul , Boffetta Paolo , Hashibe Mia 

TITLE=Sequence Variants and the Risk of Head and Neck Cancer: Pooled Analysis in the INHANCE Consortium

JOURNAL=Frontiers in Oncology

VOLUME=1

YEAR=2011

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2011.00013

DOI=10.3389/fonc.2011.00013

ISSN=2234-943X

ABSTRACT=<p>Previous molecular epidemiological studies on head and neck cancer have examined various single nucleotide polymorphisms (SNPs), but there are very few documented associations. In the International head and neck cancer epidemiology (INHANCE) consortium, we evaluated associations between SNPs in the metabolism, cell cycle, and DNA repair pathways and the risk of head and neck cancer. We analyzed individual-level pooled data from 14 European, North American, Central American, and Asia case–control studies (5,915 head and neck cancer cases and 10,644 controls) participating in the INHANCE consortium. Unconditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for SNP effects, adjusting for age, sex, race, and country. We observed an association between head and neck cancer risk and MGMT Leu84Phe heterozygotes (OR = 0.79, 95% CI = 0.68–0.93), XRCC1 Arg194Trp homozygotes Arg/Arg (OR = 2.3, 95% CI = 1.1–4.7), <italic>ADH1B</italic> Arg48His homozygotes Arg/Arg (OR = 2.7, 95% CI = 1.9–4.0), <italic>ADH1C</italic> Ile350Val homozygotes Ile/Ile (OR = 1.2, 95% CI = 1.1–1.4), and the <italic>GSTM1</italic> null genotype (OR = 1.1, 95% CI = 1.0–1.2). Among these results, <italic>MGMT</italic> Leu84Phe, <italic>ADH1B</italic> Arg48His, <italic>ADH1C</italic> Ile350Arg, and the <italic>GSTM1</italic> null genotype had fairly low false positive report probabilities (&lt;20%). We observed associations between <italic>ADH1B</italic> Arg48His, <italic>ADH1C</italic> Ile350Arg, and <italic>GSTM1</italic> null genotype and head and neck cancer risk. No functional study currently supports the observed association for <italic>MGMT</italic> Leu84Phe, and the association with <italic>XRCC1</italic> Arg194Trp may be a chance finding.</p>