Efficacies of radiotherapy in rectal cancer patients treated with total mesorectal excision or other types of surgery: an updated meta-analysis

Wang, Wenshu; Zhao, Runyuan; Liang, Xi; Liu, Manjun; Bai, Haiyan; Ge, Jianli; Yao, Binxi; Zhi, Zheng; He, Jianming

doi:10.3389/or.2025.1567818

REVIEW article

Oncol. Rev.

Sec. Oncology Reviews: Reviews

Volume 19 - 2025 | doi: 10.3389/or.2025.1567818

Efficacies of radiotherapy in rectal cancer patients treated with total mesorectal excision or other types of surgery: an updated meta-analysis

Provisionally accepted

Wenshu Wang ¹

Runyuan Zhao ²

Xi Liang ¹

Manjun Liu ¹

Haiyan Bai ¹

Jianli Ge ¹

Binxi Yao ¹

Zheng Zhi ^1*

Jianming He ^1*

¹ Hebei Province Traditional Chinese Medicine Hospital, Hebei, China
² Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, Beijing Municipality, China

The final, formatted version of the article will be published soon.

total mesorectal excision (TME); other types of surgery (not-TME-only); Overall survival (OS); long course concurrent chemoradiotherapy (LCCRT); Radiotherapy (RT); multidisciplinary treatment (MDT); locally advanced rectal cancer (LARC); local recurrence (LR); concurrent chemoradiotherapy (CRT); disease-free survival (DFS); distant metastases-free survival (DMFS); Hazard ratio (HR); Odds ratio (OR); 3-dimensional conformal radiotherapy (3D-CRT); intensity-modulated radiotherapy (IMRT); pathological complete response (pCR); total neoadjuvant therapy (TNT)

Keywords: rectal cancer, Radiotherapy, concurrent chemoradiotherapy, Surgery, TME

Received: 28 Jan 2025; Accepted: 18 Mar 2025.

Copyright: © 2025 Wang, Zhao, Liang, Liu, Bai, Ge, Yao, Zhi and He. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Zheng Zhi, Hebei Province Traditional Chinese Medicine Hospital, Hebei, China
Jianming He, Hebei Province Traditional Chinese Medicine Hospital, Hebei, China

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.