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REVIEW article

Oncol.Rev.
Sec. Oncology Reviews: Reviews
Volume 18 - 2024 | doi: 10.3389/or.2024.1434981

Construction methods and latest applications of kidney cancer organoids

Provisionally accepted
Zhiqiang Li Zhiqiang Li 1Yanqiu You Yanqiu You 2*Bingzheng Feng Bingzheng Feng 2*Chen Jibing Chen Jibing 2*Hongjun Gao Hongjun Gao 2*Fujun Li Fujun Li 1,2*
  • 1 Guangxi University, Nanning, China
  • 2 Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi Zhuang Region, China

The final, formatted version of the article will be published soon.

    Renal cell carcinoma (RCC) is one of the deadliest malignant tumors. Despite significant advances in RCC treatment over the past decade, complete remission is rarely achieved. Consequently, there is an urgent need to explore and develop new therapies to improve the survival rates and quality of life for patients. In recent years, the development of tumor organoid technology has attracted widespread attention as it can more accurately simulate the spatial structure and physiological characteristics of tumors within the human body. In this review, we summarize the main methods currently used to construct kidney cancer organoids, as well as their various biological and clinical applications. Furthermore, combining organoids with other technologies, such as co-culture techniques and microfluidic technologies, can further develop organoids and address their limitations, creating more practical models. This approach summarizes the interactions between different tissues or organs during tumor progression. Finally, we also provide an outlook on the construction and application of kidney cancer organoids. These rapidly evolving kidney cancer organoids may soon become a focal point in the development of in vitro clinical models and therapeutic research for kidney cancer.

    Keywords: Organoid, Renal cell carcinoma, Tumor Microenvironment, co-culture, Microfluidic Device, drug screening, personalized treatment

    Received: 19 May 2024; Accepted: 31 Oct 2024.

    Copyright: © 2024 Li, You, Feng, Jibing, Gao and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yanqiu You, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, 530031, Guangxi Zhuang Region, China
    Bingzheng Feng, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, 530031, Guangxi Zhuang Region, China
    Chen Jibing, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, 530031, Guangxi Zhuang Region, China
    Hongjun Gao, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, 530031, Guangxi Zhuang Region, China
    Fujun Li, Guangxi University, Nanning, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.