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REVIEW article

Oncol. Rev.
Sec. Oncology Reviews: Reviews
Volume 18 - 2024 | doi: 10.3389/or.2024.1415677

Status analysis of the cytotoxic drugs administered infusion solution quality control

Provisionally accepted
Shan Wang Shan Wang 1Feng-Ying Zhang Feng-Ying Zhang 1Xue Dou Xue Dou 1*Xiao-Lin Pan Xiao-Lin Pan 1*Chen Su Chen Su 1*Jin-Lei Tian Jin-Lei Tian 2*Dian-Ping Mu Dian-Ping Mu 1*
  • 1 Department of Pharmacy, Tianjin First Central Hospital, Tianjin, China
  • 2 School of Chemistry, Nankai University, Tianjin, China

The final, formatted version of the article will be published soon.

    Administered infusion solution is a sterile preparation that can be used directly for intravenous infusion of patients by mixed one or more intravenous drugs through aseptic operation technology. Pharmacy intravenous admixture service (PIVAS) center is a professional technical service department of hospital and administered infusion solution of inpatient mostly prepared in PIVAS. During the process of dissolution, dilution, preparation, storage, and use of intravenous drugs, the quality control of administered infusion solution can be affected by various factors. At present, there are no relevant standards and guidance documents for the quality control of administered infusion solution. Cytotoxic drugs are still the main treatment for cancer patients, and mainly prepared in PIVAS in most hospital. We mainly focused on the cytotoxic drugs quality control of administered infusion solution in the paper, and explored associated factors (diluent, container, concentration, temperature, light), physical stability (visual appearance, pH, osmolality, particulate matter), chemical stability (content) and biological stability (sterility). Almost all the literatures in this paper have insufficient data on the related factors and physicochemical stability of the administered infusion solution. Less research has been done on the sterility of administered infusion solution, with only one article involved in this. The cytotoxic drugs administered infusion solution quality control is vital to ensure the safety of drug administration for cancer patient, so it is very important to enhance associated research. This article summarized the relevant literature on the quality control of cytotoxic drugs administered infusion solution, and provided a reference for safer and more efficient use of cytotoxic drugs in clinical practice.

    Keywords: administered infusion solution, cytotoxic drugs, Physical stability, Chemical stability, Sterility

    Received: 11 Apr 2024; Accepted: 22 Nov 2024.

    Copyright: © 2024 Wang, Zhang, Dou, Pan, Su, Tian and Mu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xue Dou, Department of Pharmacy, Tianjin First Central Hospital, Tianjin, China
    Xiao-Lin Pan, Department of Pharmacy, Tianjin First Central Hospital, Tianjin, China
    Chen Su, Department of Pharmacy, Tianjin First Central Hospital, Tianjin, China
    Jin-Lei Tian, School of Chemistry, Nankai University, Tianjin, China
    Dian-Ping Mu, Department of Pharmacy, Tianjin First Central Hospital, Tianjin, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.