AUTHOR=Xu Yangheng , Hong Zhisheng , Yu Sheng , Huang Ronghan , Li Kunqi , Li Ming , Xie Sisi , Zhu Lvyun 

TITLE=Fresh Insights Into SLC25A26: Potential New Therapeutic Target for Cancers: A Review

JOURNAL=Oncology Reviews

VOLUME=18

YEAR=2024

URL=https://www.frontiersin.org/journals/oncology-reviews/articles/10.3389/or.2024.1379323

DOI=10.3389/or.2024.1379323

ISSN=1970-5557

ABSTRACT=<p><italic>SLC25A26</italic> is the only known human mitochondrial S-adenosylmethionine carrier encoding gene. Recent studies have shown that <italic>SLC25A26</italic> is abnormally expressed in some cancers, such as cervical cancer, low-grade glioma, non-small cell lung cancer, and liver cancer, which suggests <italic>SLC25A26</italic> can affect the occurrence and development of some cancers. This article in brief briefly reviewed mitochondrial S-adenosylmethionine carrier in different species and its encoding gene, focused on the association of <italic>SLC25A26</italic> aberrant expression and some cancers as well as potential mechanisms, summarized its potential for cancer prognosis, and characteristics of mitochondrial diseases caused by <italic>SLC25A26</italic> mutation. Finally, we provide a brief expectation that needs to be further investigated. We speculate that <italic>SLC25A26</italic> will be a potential new therapeutic target for some cancers.</p>