Geriatric Nutritional Risk Index as a Predictor of Mortality in Women with Chronic Inflammatory Airway Disease: Evidence from NHANES 1999-2018

Zhao Chen ¹ Youli Wen ¹ Wenqiang Li ¹ Jingshan Bai ² Peng Zhou ³ Qian He ⁴ Deng Zhi-Ping ^1*

• ¹ Zigong First People's Hospital, Zigong, China
• ² Xiong'an Xuanwu Hospital, Xiong'an New Area, China
• ³ Changsha Medical University, Changsha, Hunan Province, China
• ⁴ West China Second University Hospital, Sichuan University, Chengdu, Sichuan Province, China

The incidence of Chronic Inflammatory Airway Diseases (CIAD) has been steadily increasing, making it a significant contributor to the global disease burden. Additionally, the risk of airway diseases in elderly women continues to rise each year, with nutritional factors playing a crucial role in the progression of CIAD. The Geriatric Nutritional Risk Index (GNRI) is a novel tool for assessing individual nutritional status. This study aims to assess the relationship between GNRI and the risk of all-cause and cardiovascular mortality in elderly women with CIAD, providing guidance for nutritional interventions to reduce mortality risk.lowest risks of all-cause mortality (HR = 0.40, 95% CI: 0.22-0.72, P < 0.05) and cardiovascular mortality (HR = 0.29, 95% CI: 0.11-0.78, P < 0.05).The RCS analysis demonstrated a nonlinear association between GNRI and both all-cause and cardiovascular mortality (P for nonlinearity < 0.001).In elderly women with CIAD, lower GNRI levels are associated with an increased mortality risk. GNRI may serve as a potential predictive tool for both all-cause and cardiovascular mortality, providing valuable insights for nutritional interventions and clinical decision-making.