AUTHOR=Tang Dupeng , Lin Lanqing , Zheng Yixin 

TITLE=The association between oxidative balance score and muscular dystrophies

JOURNAL=Frontiers in Nutrition

VOLUME=11

YEAR=2024

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1465486

DOI=10.3389/fnut.2024.1465486

ISSN=2296-861X

ABSTRACT=<sec><title>Introduction</title><p>This research utilized data from the NHANES 2011–2018 study to investigate the connection between the Oxidative Balance Score (OBS) and muscular dystrophies.</p></sec><sec><title>Methods</title><p>This study is a cross-sectional, observational, secondary analysis utilizing data from the NHANES 2011-2018. Spearman’s correlation, chi-square tests, logistic regression, and restricted cubic spline plots were employed for statistical analyses.</p></sec><sec><title>Results</title><p>This association remained significant after adjustment for various demographic and medical history factors (For continuous OBS: crude model, odds ratio [OR], 0.95, 95% confidence interval [CI:] 0.94, 0.97, <italic>p</italic> &lt; 0.001; Model 1, OR, 0.94, 95% CI: 0.92, 0.96, <italic>p</italic> &lt; 0.001; Model 2, OR, 0.95, 95% CI: 0.93, 0.97, <italic>p</italic> &lt; 0.001; Model 3, OR, 0.95, 95% CI: 0.93, 0.97, <italic>p</italic> &lt; 0.001; In quartile Q4 vs. Q1: Crude model, OR, 0. 42, 95% CI: 0.26, 0.66, <italic>p</italic> &lt; 0.001; Model 1, OR, 0.33, 95% CI: 0.21, 0.52, <italic>p</italic> &lt; 0.001; Model 2, OR, 0.37, 95% CI: 0.23, 0.58, <italic>p</italic> &lt; 0.001; Model 3, OR, 0.38, 95% CI: 0.23, 0.60, <italic>p</italic> &lt; 0.001). Restricted cubic spline (RCS) analysis further supported this inverse relationship, suggesting that OBS values above 10 may confer protection against muscular dystrophies (<italic>p</italic> for overall &lt;0.001, <italic>p</italic> for non-linear = 0.536). However, the relationship between OBS and muscular dystrophies was not statistically significant in the subgroups with education level below high school, presence of cancer, or diabetes (<italic>p</italic> = 0.735, <italic>p</italic> = 0.574, <italic>p</italic> = 0.409, respectively).</p></sec><sec><title>Conclusion</title><p>The study found a significant inverse correlation between the OBS and muscular dystrophies, suggesting that individuals with higher oxidative balance had a lower risk of developing muscular dystrophies. The study highlights the potential role of oxidative balance in muscular dystrophies prevention and management.</p></sec>