AUTHOR=Wang Jibing , Zhang Guoyan , Wang Duona , Yan Yuanyuan , Yang Qin 

TITLE=Effects of nano-Rhodiola rosea combined with treadmill exercise on anti-exercise fatigue in rats

JOURNAL=Frontiers in Nutrition

VOLUME=11

YEAR=2024

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1446944

DOI=10.3389/fnut.2024.1446944

ISSN=2296-861X

ABSTRACT=<sec id="sec1"><title>Objective</title><p>To explore the potential strategies and mechanisms for enhancing the bioavailability of <italic>Rhodiola rosea</italic>.</p></sec><sec id="sec2"><title>Methods</title><p>36 Sprague–Dawley rats (8-weeks-old) were randomly assigned to six groups (<italic>n</italic> = 6 per group). Groups I and II received nano-dose forms of <italic>R. rosea</italic>, groups III and IV received normal dose form of <italic>R. rosea</italic>, and groups V and VI served as distilled water control groups. Groups II, IV, and VI were combined with moderate -intensity treadmill exercise. Each group received a daily gavage with 0.5 mL of nano -<italic>R. rosea</italic> solution (0.01 mg/mL), normal <italic>R. rosea</italic> solution, and distilled water. All rats were subjected to exhaustive swimming after 4 weeks. Outcome measures include GSH-px activity, T-AOC activity, MDA content, hepatic glycogen content, and T-SOD activity.</p></sec><sec id="sec3"><title>Results</title><p>For plasma MDA content, group I was lower than group III (<italic>p</italic> &lt; 0.01) and group V (<italic>p</italic> &lt; 0.01), group II was lower than group III (<italic>p</italic> &lt; 0.01), group VI was higher than group II (<italic>p</italic> &lt; 0.05) and group IV (<italic>p</italic> &lt; 0.05). For plasma T-AOC activity, group II was higher than group VI (<italic>p</italic> &lt; 0.01). For plasma GSH-px activity, group I was lower than group IV (<italic>p</italic> &lt; 0.05), groups II, III, and IV were higher than group V (<italic>p</italic> &lt; 0.05), and group V was lower than that of group VI (<italic>p</italic> &lt; 0.05). For T-SOD activity of quadriceps muscle, groups I and III were higher than that in group V (<italic>p</italic> &lt; 0.05).</p></sec><sec id="sec4"><title>Conclusion</title><p><italic>R. rosea</italic> has a positive effect on anti-exercise fatigue in rats, with the nano-dosage form of <italic>R. rosea</italic> showing more significant efficacy than the normal form especially combined with aerobic exercise.</p></sec>