AUTHOR=Li Siyue , Ren Qingqian , Song Zixuan , Liu Baixue , Wang Dan , Shang Yanna , Wang Hao 

TITLE=Associations of minerals intake with colorectal cancer risk in the prostate, lung, colorectal, ovarian cancer screening trial

JOURNAL=Frontiers in Nutrition

VOLUME=11

YEAR=2024

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1445369

DOI=10.3389/fnut.2024.1445369

ISSN=2296-861X

ABSTRACT=<sec id="sec1"><title>Objective</title><p>Exploring the association between common mineral intake and the risk of colorectal cancer (CRC).</p></sec><sec id="sec2"><title>Methods</title><p>We utilized the multivariate Cox proportional hazards model to assess the association between intake of minerals and the risk of CRC, estimating hazard ratios (HRs) and 95% confidence intervals (CIs).</p></sec><sec id="sec3"><title>Results</title><p>A total of 101,686 eligible participants were included in the analysis of this study, including 1,100 CRC cases. After adjusting for potential confounders, we found that total zinc intake (HR<sub>Q4vs.Q1</sub>: 0.79, 95%CI 0.67–0.93; <italic>P</italic> for trend &lt;0.05), iron intake (HR<sub>Q4vs.Q1</sub>: 0.81, 95%CI 0.68–0.96; <italic>P</italic> for trend &lt;0.05), copper intake (HR<sub>Q4vs.Q1</sub>: 0.80, 95%CI 0.68–0.95; <italic>P</italic> for trend &lt;0.05), selenium intake (HR<sub>Q4vs.Q1</sub>: 0.83, 95%CI 0.69–0.98; <italic>P</italic> for trend &lt;0.05) were significantly negatively associated with the incidence of CRC, but magnesium intake in the appropriate range is associated with a reduced risk of CRC (HR<sub>Q3vs.Q1</sub>: 0.77, 95%CI 0.65–0.91; <italic>P</italic> for trend &gt;0.05).</p></sec><sec id="sec4"><title>Conclusion</title><p>Our findings suggested that an appropriate intake of total zinc, iron, copper, selenium and magnesium were associated with lower CRC risk.</p></sec>