AUTHOR=Xu Duojie , Yuan Ling , Meng Fandi , Lu Doudou , Che Mengying , Yang Yating , Liu Wenjing , Nan Yi 

TITLE=Research progress on antitumor effects of sea buckthorn, a traditional Chinese medicine homologous to food and medicine

JOURNAL=Frontiers in Nutrition

VOLUME=11

YEAR=2024

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1430768

DOI=10.3389/fnut.2024.1430768

ISSN=2296-861X

ABSTRACT=<p>Sea buckthorn (<italic>Hippophae Fructus</italic>), as a homologous species of medicine and food, is widely used by Mongolians and Tibetans for its anti-tumor, antioxidant and liver-protecting properties. In this review, the excellent anti-tumor effect of sea buckthorn was first found through network pharmacology, and its active components such as isorhamnetin, quercetin, gallic acid and protocatechuic acid were found to have significant anti-tumor effects. The research progress and application prospect of sea buckthorn and its active components in anti-tumor types, mechanism of action, liver protection, anti-radiation and toxicology were reviewed, providing theoretical basis for the development of sea buckthorn products in the field of anti-tumor research and clinical application.</p>