AUTHOR=Zhao Xiaoxuan , Hua Lijiangshan , Jin Kaili , Sun Qiuhua , Wang Rongyun 

TITLE=Association between oxidative balance score and skeletal muscle mass and strength: NHANES from 2011 to 2018

JOURNAL=Frontiers in Nutrition

VOLUME=11

YEAR=2024

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1414161

DOI=10.3389/fnut.2024.1414161

ISSN=2296-861X

ABSTRACT=<sec id="sec1"><title>Objective</title><p>Oxidative stress is a risk factor for sarcopenia. The Oxidative Balance Score (OBS) is a widely employed tool for evaluating the oxidative stress-related exposures from dietary and lifestyle factors. In this study, we aimed to conducted to explore the relationship between OBS and skeletal muscle mass and strength.</p></sec><sec id="sec2"><title>Methods</title><p>6,438 subjects from 2011 to 2018 and 5,414 from 2011 to 2014 from the National Health and Nutrition Examination Survey (NHANES) were selected for analysis. The correlations between OBS and skeletal muscle mass and handgrip strength were investigated using multivariate logistic regression and linear regression analysis.</p></sec><sec id="sec3"><title>Results</title><p>Compared with lowest OBS, participants with OBS in the highest quartile had lower risk of low skeletal muscle mass (OR = 0.173 (0.120 ~ 0.248), <italic>p</italic> &lt; 0.0001) and low handgrip strength (<italic>β</italic> = 0.173 (0.120 ~ 0.248), <italic>p</italic> = 0.011). The negative association also were found between dietary/lifestyle OBS and skeletal muscle mass (OR = 0.268 (0.178 ~ 0.404), <italic>p</italic> &lt; 0.0001; OR = 0.231 (0.130 ~ 0.410), <italic>p</italic> &lt; 0.0001) and handgrip strength (<italic>β</italic> = 1.812 (0.555 ~ 3.071), <italic>p</italic> = 0.008; <italic>β</italic> = −2.255 (−3.430 ~ −1.079), <italic>p</italic> &lt; 0.001) independently. The positive association remains significant, especially among men and those with higher education levels by subgroup analysis.</p></sec><sec id="sec4"><title>Conclusion</title><p>All of these results indicated a negative association between OBS and low skeletal muscle mass and handgrip strength. An antioxidant-rich diet and healthy lifestyle are crucial for enhancing skeletal muscle mass and strength.</p></sec>