AUTHOR=Tamayo-Trujillo Rafael , Ruiz-Pozo Viviana A. , Cadena-Ullauri Santiago , Guevara-Ramírez Patricia , Paz-Cruz Elius , Zambrano-Villacres Raynier , Simancas-Racines Daniel , Zambrano Ana Karina TITLE=Molecular mechanisms of semaglutide and liraglutide as a therapeutic option for obesity JOURNAL=Frontiers in Nutrition VOLUME=11 YEAR=2024 URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1398059 DOI=10.3389/fnut.2024.1398059 ISSN=2296-861X ABSTRACT=

Obesity, a chronic global health problem, is associated with an increase in various comorbidities, such as cardiovascular disease, type 2 diabetes mellitus, hypertension, and certain types of cancer. The increasing global prevalence of obesity requires research into new therapeutic strategies. Glucagon-like peptide-1 receptor agonists, specifically semaglutide and liraglutide, designed for type 2 diabetes mellitus treatment, have been explored as drugs for the treatment of obesity. This minireview describes the molecular mechanisms of semaglutide and liraglutide in different metabolic pathways, and its mechanism of action in processes such as appetite regulation, insulin secretion, glucose homeostasis, energy expenditure, and lipid metabolism. Finally, several clinical trial outcomes are described to show the safety and efficacy of these drugs in obesity management.