AUTHOR=Laurent Nicole 

TITLE=Retrospective case study: ketogenic metabolic therapy in the effective management of treatment-resistant depressive symptoms in bipolar disorder

JOURNAL=Frontiers in Nutrition

VOLUME=11

YEAR=2024

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1394679

DOI=10.3389/fnut.2024.1394679

ISSN=2296-861X

ABSTRACT=<p>This retrospective case study assessed Ketogenic Metabolic Therapy’s (KMT) efficacy in a bipolar disorder patient with treatment-resistant depressive symptoms insufficiently controlled by weekly ketamine treatments. Monitoring included relevant biomarkers of ketone production and macronutrient levels, alongside mood evaluations through the Generalized Anxiety Disorder-7 (GAD-7), Depression Anxiety Stress Scales (DASS), and PTSD Checklist for DSM-5 (PCL-5), showing mood stabilization and improved functionality. Qualitative analysis revealed sub-stantial enhancements in functioning, life quality, and mental well-being. This study enriches the metabolic psychiatry literature, emphasizing KMT’s potential benefits by integrating quantitative data from recognized psychiatric assessment tools and qualitative insights.</p>