AUTHOR=Villar-Taibo Rocío , Vidal-Casariego Alfonso , Santamaría-Nieto Alicia , Cantón-Blanco Ana , Crujeiras Ana B. , Lugo Rodríguez Gloria , Rodríguez-Carnero Gemma , Pita Gutiérrez Francisco , Fernández Pombo Antía , Díaz-López Everardo , Román Eyo Andrea , Rodríguez Lavandeira Uxía , Pena-Dubra Alberto , Martínez-Olmos Miguel Ángel 

TITLE=Efficacy of a new immunonutrition formula with extra virgin olive oil in the reduction of complications in surgeries of upper digestive tract tumors

JOURNAL=Frontiers in Nutrition

VOLUME=11

YEAR=2024

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1384145

DOI=10.3389/fnut.2024.1384145

ISSN=2296-861X

ABSTRACT=<sec id="sec1"><title>Background</title><p>To demonstrate whether a nutritional supplement enriched with arginine, nucleotides, omega-3 fatty acids, and extra virgin olive oil reduces postoperative complications in patients with tumors in the upper digestive tract.</p></sec><sec id="sec2"><title>Methods</title><p>A randomized, controlled, double-blind, multicenter clinical trial, in which a new immunomodulatory formula with extra virgin olive oil was compared with a standard isoprotein and isoenergetic formula. Patients with gastric, esophageal or biliopancreatic tumors were recruited to receive two units of immunomodulatory formula or control, 5 days before the surgical intervention.</p></sec><sec id="sec3"><title>Results</title><p>A total of 119 patients were recruited. There was a significant reduction in the number of reinterventions (7.7 vs. 20.4%; <italic>p</italic> = 0.044) in the intervention group. There was a significant reduction in the development of fistulas in patients with phase angles &gt;5.7°. Also, there were fewer readmissions after biliopancreatic surgeries (0.0 vs. 100%; <italic>p</italic> = 0.014). The length of hospital stay was similar between groups; however, with the immunomodulatory formula, the patients exhibited greater phase angle at the end of follow-up.</p></sec><sec id="sec4"><title>Conclusion</title><p>The immunomodulatory formula with extra virgin olive oil administered 5 days before surgery for stomach, esophageal and biliopancreatic tumors improved cellular health and reduced postoperative complications.</p><p><bold>Clinical trial registration</bold>: [<ext-link xlink:href="https://clinicaltrials.gov/" ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink">https://clinicaltrials.gov/</ext-link>], identifier [NCT04027088].</p></sec>