AUTHOR=Rivera-Iñiguez Ingrid , Hunot-Alexander Claudia , Sepúlveda-Villegas Maricruz , Campos-Medina Liliana , Roman Sonia 

TITLE=Relationship between energy balance and reward system gene polymorphisms and appetitive traits in young Mexican subjects

JOURNAL=Frontiers in Nutrition

VOLUME=11

YEAR=2024

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1373578

DOI=10.3389/fnut.2024.1373578

ISSN=2296-861X

ABSTRACT=<sec id="sec1"><title>Introduction</title><p>Appetitive traits are influenced by the interplay between genetic and environmental factors. This study aimed to explore the relationship between gene polymorphisms involved in the regulation of energy balance and food reward and appetitive traits in young Mexican subjects.</p></sec><sec id="sec2"><title>Methods</title><p>This cross-sectional study involved 118 university freshman undergraduates who completed the Adult Eating Behaviour Questionnaire for Spanish speakers (AEBQ-Esp) to assess their appetitive traits. A real-time PCR system was employed to determine gene polymorphisms involved in energy balance (<italic>LEP</italic> rs7799039, <italic>MC4R</italic> rs17782313, <italic>FTO</italic> rs9939609, <italic>GHRL</italic> rs696217), and reward system (<italic>DRD2/ANKK1</italic> Taq1A rs1800497 and <italic>COMT</italic> rs4680).</p></sec><sec id="sec3"><title>Results</title><p>The mean age of participants was 20.14 ± 3.95 years, 71.2% were women and their mean BMI was 23.52 ± 4.05 kg/m<sup>2</sup>. <italic>COMT</italic> Met allele carriers presented a significantly higher “Emotional overeating” mean score than Val allele carriers (2.63 ± 0.70 vs. 2.23 ± 0.70, <italic>p</italic> = 0.028). The <italic>MC4R</italic> CC + CT genotype correlated positively with “Emotional overeating” (Phi = 0.308, <italic>p</italic> = 0.01). The <italic>COMT</italic> MetMet+MetVal genotype correlated with higher “Emotional overeating” (<italic>r</italic> = 0.257, <italic>p</italic> = 0.028; Phi = 0.249, <italic>p</italic> = 0.033). The protective genotype <italic>FTO</italic> TT correlated positively with “Emotional undereating” (Phi = 0.298, <italic>p</italic> = 0.012). Carriers of the risk genotype <italic>MC4R</italic> CC + CT presented a higher risk of “Emotional overeating” than TT carriers (OR = 2.4, 95% CI 1.3–4.8, <italic>p</italic> = 0.034). Carriers of the risk genotype <italic>COMT</italic> MetMet+MetVal (OR = 3.4, 95% CI 1.1–10.3, <italic>p</italic> = 0.033), were associated with a higher risk of “Emotional overeating” than ValVal carriers. The protective <italic>FTO</italic> genotype TT was associated with “Emotional undereating” (OR = 1.8, 95% CI 1.1–9.1, <italic>p</italic> = 0.014).</p></sec><sec id="sec4"><title>Discussion</title><p>The study found a relationship between the protective genotypes of <italic>FTO</italic> TT and “Emotional undereating” and risk genotypes of <italic>COMT</italic> Met/Met+Met/Val and <italic>MC4R</italic> CC + CT with “Emotional overeating.” These genetic factors may increase weight gain by enhancing hedonic food consumption and reducing satiety control. Future studies should focus on replication studies in ethnically diverse young adults and life stages to explore the relationship between polymorphisms and appetitive traits and weight. This will help tailor personalized nutrigenetic strategies to counteract disordered eating patterns leading to obesity and associated co-morbidities.</p></sec>