AUTHOR=Rafieipoor Alireza , Torkaman Mahdie , Azaryan Fatemeh , Tavakoli Aryan , Mohammadian Mohammad Keshavarz , Kohansal Atefeh , Shafaei Hanieh , Mirzaee Pouya , Motiee Bijarpasi Zeinab , Bahmani Parsa , Khosravi Masoud , Doaei Saeid , Gholamalizadeh Maryam 

TITLE=Effectiveness of omega-3 fatty acid supplementation for pruritus in patients undergoing hemodialysis

JOURNAL=Frontiers in Nutrition

VOLUME=11

YEAR=2024

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1328469

DOI=10.3389/fnut.2024.1328469

ISSN=2296-861X

ABSTRACT=<sec id="sec1"><title>Background</title><p>Patients undergoing hemodialysis (HD) frequently experience the chronic kidney disease-associated pruritus (CKD-aP).</p></sec><sec id="sec2"><title>Objective</title><p>The aim of this study was to investigate the effectiveness of omega-3 supplementation in the management of CKD-aP in patients undergoing hemodialysis.</p></sec><sec id="sec3"><title>Methods</title><p>In this triple blind, randomized clinical trial, the effect of the omega-3 supplement on uremic CKD-aP was assessed in 112 chronic hemodialysis patients at Caspian Hemodialysis Center in Rasht, Iran. Patients were randomly divided into the intervention group receiving omega-3 supplements (3 g/day) and the control group receiving placebo containing MCT oil for 2 months.</p></sec><sec id="sec4"><title>Results</title><p>Omega-3 supplementation had no effect on CKD-aP. The results did not change after adjusting for age and sex, additional adjustments for weight, height, physical activity, smoking, and alcohol use, additional adjustments for underlying diseases and weight, height, physical activity, smoking, and drinking alcohol, and further adjustments for underlying diseases and biochemical indices.</p></sec><sec id="sec5"><title>Discussion</title><p>Omega-3 supplementation for 2 months had no effect on CKD-aP in patients with CKD. Further studies with longer duration are warranted.</p></sec><sec id="sec89"><title>Clinical Trial Registration</title><p><ext-link xlink:href="https://www.irct.ir/trial/66638" ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink">https://www.irct.ir/trial/66638</ext-link>, IRCT20151226025699N6</p></sec>