AUTHOR=O’Neill Simone , Minehan Michelle , Knight-Agarwal Catherine R. , Pyne David B. TITLE=Alterations in gut microbiota caused by major depressive disorder or a low FODMAP diet and where they overlap JOURNAL=Frontiers in Nutrition VOLUME=10 YEAR=2024 URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2023.1303405 DOI=10.3389/fnut.2023.1303405 ISSN=2296-861X ABSTRACT=
Beneficial changes in microbiota observed in individuals with a major depressive disorder (MDD) may be initiated with a low fermentable oligosaccharide, disaccharide, monosaccharide, and polyol (FODMAP) elimination diet. Academic Search Ultimate, APA PsychINFO, Cochrane Library, MEDLINE, Scopus and Web of Science were searched for original research documenting differences in microbiota in MDD or changes with a low FODMAP diet in adults (age 18 years +). Studies with fecal microbiota, 16 s RNA sequencing and QIIME pipelines were included. Studies using antibiotics, probiotics, and medications such as antidepressants were excluded. Additionally, studies based on a single gender were excluded as gender impacts microbiota changes in MDD. Four studies addressed differences in microbiota with MDD and another four assessed shifts occurring with a low FODMAP diet. The abundance of