AUTHOR=Ding Ning , Zeng Zhao , Luo Ju , Li Keng 

TITLE=The cross-sectional relationship between vitamin C and high-sensitivity C-reactive protein levels: insights from NHANES database

JOURNAL=Frontiers in Nutrition

VOLUME=10

YEAR=2023

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2023.1290749

DOI=10.3389/fnut.2023.1290749

ISSN=2296-861X

ABSTRACT=<sec id="sec1"><title>Background</title><p>Ascorbic acid or vitamin C has antioxidant and anti-inflammatory properties that may impact markers of inflammation like C-reactive protein (CRP). However, studies specifically on vitamin C and high-sensitivity CRP (hs-CRP) have been scarce.</p></sec><sec id="sec2"><title>Methods</title><p>We conducted a cross-sectional analysis of the National Health and Nutrition Examination Survey 2017–2018 dataset including 5,380 U.S. adults aged ≥20 years. Multiple regression models examined the relationship between plasma vitamin C and serum hs-CRP while adjusting for potential confounders. Stratified analyses and curve fitting assessed effect modification and nonlinearity.</p></sec><sec id="sec3"><title>Results</title><p>An inverse association was found between plasma vitamin C and serum hs-CRP overall (β = −0.025, 95% CI: −0.033 to −0.017, <italic>p</italic> &lt; 0.00001) and in subgroups except for the “other Hispanic” subgroup in model II (β = −0.009, 95% CI: (−0.040, 0.023), <italic>p</italic> = 0.5885). The relationship was nonlinear, with the greatest hs-CRP reduction observed up to a plasma vitamin C level of 53.1 μmol/L.</p></sec><sec id="sec4"><title>Conclusion</title><p>The results showed a non-linear negative correlation between vitamin C levels and hs-CRP in adults. These results suggest vitamin C intake may reduce inflammation and cardiovascular risk, but only up to 53.1 μmol/L plasma vitamin C.</p></sec>